Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.L212insFs

c.636dupT

Surrounding Variants

1 paper

NM_003000.3

p.M213fs

c.637_638fs

2 papers

NM_003000.3

p.M213L

c.637A>T

1 paper

NM_003000.3

p.M213V

c.637A>G

2 papers

NM_003000.3

p.M213L

c.637A>C

1 paper

NM_003000.3

p.L212delFs

c.635_636delAA

6 papers

NM_003000.3

p.M213insFs

c.637dupA

1 paper

NM_003000.3

p.M213T

c.638T>C

1 paper

NM_003000.3

p.L212L

c.636T>C

1 paper

NM_003000.3

p.L212P

c.635T>C

1 paper

NM_003000.3

p.L212H

c.635T>A

3 papers

NM_003000.3

p.M213fs

c.637_638fs

10 papers

NM_003000.3

p.Q214*

c.640C>T