Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_003000.3

p.D204fs

c.610_611fs

Surrounding Variants

1 paper

NM_003000.3

p.D204E

c.612C>G

1 paper

NM_003000.3

p.D204E

c.612C>A

1 paper

NM_003000.3

p.D204Y

c.610G>T

3 papers

NM_003000.3

p.N202_G203insFs

c.605_609dup5

1 paper

NM_003000.3

p.K205R

c.614A>G

1 paper

NM_003000.3

p.K205N

c.615A>T

1 paper

NM_003000.3

p.K205N

c.615A>C

2 papers

NM_003000.3

p.G203fs

c.607_608fs

2 papers

NM_003000.3

p.G203delFs

c.608delC

1 paper

NM_003000.3

p.Y206H

c.616T>C

1 paper

NM_003000.3

p.G203A

c.608G>C

2 papers

NM_003000.3

p.G203E

c.608G>A