Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_003000.3

p.W200*

c.600G>A

Surrounding Variants

45 papers

NM_003000.3

p.W200C

c.600G>T

38 papers

NM_003000.3

p.W200C

c.600G>C

2 papers

NM_003000.3

p.W200insFs

c.600dupG

3 papers

NM_003000.3

p.P197_W200ins1

c.589_600dup12

1 paper

NM_003000.3

p.W201G

c.601T>G

2 papers

NM_003000.3

p.W200L

c.599G>T

1 paper

NM_003000.3

p.W200insFs

c.598dupT

8 papers

NM_003000.3

p.W200*

c.599G>A

1 paper

NM_003000.3

p.Y199del1

c.595_596delGTA

2 papers

NM_003000.3

p.W200R

c.598T>C

3 papers

NM_003000.3

p.W200R

c.598T>A

7 papers

NM_003000.3

p.W201*

c.602G>A