Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.P197H

c.590C>A

Surrounding Variants

3 papers

NM_003000.3

p.P197L

c.590C>T

46 papers

NM_003000.3

p.P197R

c.590C>G

7 papers

NM_003000.3

p.P197S

c.589C>T

1 paper

NM_003000.3

p.S193_C196ins1

c.577_588dup12

4 papers

NM_003000.3

p.P197fs

c.589_590fs

2 papers

NM_003000.3

p.C196W

c.588C>G

1 paper

NM_003000.3

p.C196*

c.588C>A

6 papers

NM_003000.3

p.S198fs

c.592_593fs

1 paper

NM_003000.3

p.S198G

c.592A>G

5 papers

NM_003000.3

p.S198R

c.592A>C

17 papers

NM_003000.3

p.P197delFs

c.591delG

1 paper

NM_003000.3

p.C196F

c.587G>T