Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.T194S

c.580A>T

Surrounding Variants

1 paper

NM_003000.3

p.T194fs

c.580_581fs

2 papers

NM_003000.3

p.T194A

c.580A>G

1 paper

NM_003000.3

p.T194S

c.581C>G

1 paper

NM_003000.3

p.S193T

c.578G>C

1 paper

NM_003000.3

p.S193N

c.578G>A

1 paper

NM_003000.3

p.T194_S195insFs

c.582_583insTA

1 paper

NM_003000.3

p.S193G

c.577A>G

1 paper

NM_003000.3

p.S195R

c.583A>C

2 papers

NM_003000.3

p.C191_C192del2

c.571_575del6

1 paper

NM_003000.3

p.S195T

c.584G>C

1 paper

NM_003000.3

p.S195N

c.584G>A

1 paper

NM_003000.3

p.C192insFs

c.574dupT