Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_003000.3

p.C191Y

c.572G>A

Surrounding Variants

1 paper

NM_003000.3

p.C191insFs

c.572_573insC

1 paper

NM_003000.3

p.C191S

c.572G>C

1 paper

NM_003000.3

p.C191S

c.571T>A

3 papers

NM_003000.3

p.C192G

c.574T>G

34 papers

NM_003000.3

p.C192R

c.574T>C

4 papers

NM_003000.3

p.C192S

c.574T>A

1 paper

NM_003000.3

p.C192fs

c.574_575fs

1 paper

NM_003000.3

p.A190A

c.570C>G

1 paper

NM_003000.3

p.C192insFs

c.574dupT

4 papers

NM_003000.3

p.C192S

c.575G>C

8 papers

NM_003000.3

p.C192Y

c.575G>A

1 paper

NM_003000.3

p.C189_A190delFs

c.567_568delCA