Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.C189_A190delFs

c.567_568delCA

Surrounding Variants

2 papers

NM_003000.3

p.A190T

c.568G>A

1 paper

NM_003000.3

p.C186_C189delFs

c.558_567del10

1 paper

NM_003000.3

p.A190A

c.570C>G

1 paper

NM_003000.3

p.C189_A190insFs

c.567_568ins4

2 papers

NM_003000.3

p.C189W

c.567T>G

1 paper

NM_003000.3

p.C191S

c.571T>A

4 papers

NM_003000.3

p.C189F

c.566G>T

1 paper

NM_003000.3

p.C191insFs

c.572_573insC

1 paper

NM_003000.3

p.C191S

c.572G>C

1 paper

NM_003000.3

p.C189S

c.566G>C

14 papers

NM_003000.3

p.C191Y

c.572G>A

2 papers

NM_003000.3

p.C189Y

c.566G>A