Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.Y184N

c.550T>A

Surrounding Variants

1 paper

NM_003000.3

p.Y184_E185insTC

c.550_554ins6

2 papers

NM_003000.3

p.Y184H

c.550T>C

1 paper

NM_003000.3

p.G182_Y184delFs

c.544_550del7

3 papers

NM_003000.3

p.Y184Y

c.552C>T

3 papers

NM_003000.3

p.Y184*

c.552C>G

3 papers

NM_003000.3

p.Y184*

c.552C>A

1 paper

NM_003000.3

p.Y184delins

c.550_552delinsATACAG

4 papers

NM_003000.3

p.E185*

c.553G>T

1 paper

NM_003000.3

p.E185insFs

c.553_554insTG

1 paper

NM_003000.3

p.E185insFs

c.553_554insA

5 papers

NM_003000.3

p.E185K

c.553G>A

1 paper

NM_003000.3

p.E185fs

c.553_554fs