Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.E175insFs

c.523dupG

Surrounding Variants

1 paper

NM_003000.3

p.E175G

c.524A>G

2 papers

NM_003000.3

p.E175delFs

c.523delC

1 paper

NM_003000.3

p.K167_I174delFs

c.500_521del22

2 papers

NM_003000.3

p.E175*

c.523G>T

1 paper

NM_003000.3

p.E175Q

c.523G>C

3 papers

NM_003000.3

p.E175K

c.523G>A

2 papers

NM_003000.3

p.E175fs

c.523_524fs

1 paper

NM_003000.3

p.E175fs

c.523_524fs

7 papers

NM_003000.3

p.E176*

c.526G>T

1 paper

NM_003000.3

p.I174M

c.522A>G

2 papers

NM_003000.3

p.I174T

c.521T>C

3 papers

NM_003000.3

p.E176G

c.527A>G