Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.Y170insFs

c.508dupT

Surrounding Variants

1 paper

NM_003000.3

p.Y170insFs

c.509_510insAA

1 paper

NM_003000.3

p.Y170*

c.510T>G

1 paper

NM_003000.3

p.Y170*

c.510T>A

1 paper

NM_003000.3

p.Q168_Q169del2

c.502_506del6

5 papers

NM_003000.3

p.L171L

c.511C>T

11 papers

NM_003000.3

p.G166_Y170del5

c.496_509del15

1 paper

NM_003000.3

p.Q169R

c.506A>G

1 paper

NM_003000.3

p.Q169fs

c.505_506fs

8 papers

NM_003000.3

p.Q169*

c.505C>T

2 papers

NM_003000.3

p.Q168insFs

c.503dupA

1 paper

NM_003000.3

p.Q168Q

c.504G>A

2 papers

NM_003000.3

p.Q172*

c.514C>T