Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.E165_G166delFs

c.494_497del4

Surrounding Variants

1 paper

NM_003000.3

p.G166D

c.497G>A

5 papers

NM_003000.3

p.K167*

c.499A>T

1 paper

NM_003000.3

p.K167Q

c.499A>C

2 papers

NM_003000.3

p.G166delFs

c.498delG

2 papers

NM_003000.3

p.G166C

c.496G>T

1 paper

NM_003000.3

p.G166R

c.496G>C

1 paper

NM_003000.3

p.G166S

c.496G>A

1 paper

NM_003000.3

p.K167fs

c.499_500fs

1 paper

NM_003000.3

p.Q168fs

c.502_503fs

7 papers

NM_003000.3

p.Q168*

c.502C>T

3 papers

NM_003000.3

p.E165delFs

c.493delC

1 paper

NM_003000.3

p.E165*

c.493G>T