Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.D161V

c.482A>T

Surrounding Variants

4 papers

NM_003000.3

p.D161G

c.482A>G

2 papers

NM_003000.3

p.D161delFs

c.481delC

3 papers

NM_003000.3

p.D161fs

c.481_482fs

2 papers

NM_003000.3

p.D161N

c.481G>A

2 papers

NM_003000.3

p.K160del1

c.478_480delCTT

1 paper

NM_003000.3

p.K160delFs

c.478delT

1 paper

NM_003000.3

p.K160M

c.479A>T

1 paper

NM_003000.3

p.K160insFs

c.479_480insGT

1 paper

NM_003000.3

p.K160*

c.478A>T

77 papers

NM_003000.3

p.S163P

c.487T>C

1 paper

NM_003000.3

p.K159fs

c.475_476fs

1 paper

NM_003000.3

p.K159insFs

c.475dupA