Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.K159*

c.475A>T

Surrounding Variants

1 paper

NM_003000.3

p.K159E

c.475A>G

1 paper

NM_003000.3

p.K158delFs

c.473delT

1 paper

NM_003000.3

p.K159fs

c.475_476fs

1 paper

NM_003000.3

p.K159insFs

c.475dupA

1 paper

NM_003000.3

p.K159delFs

c.475delT

1 paper

NM_003000.3

p.K160*

c.478A>T

1 paper

NM_003000.3

p.K158*

c.472A>T

1 paper

NM_003000.3

p.L157del1

c.469_471delCAA

2 papers

NM_003000.3

p.L157fs

c.469_470fs

1 paper

NM_003000.3

p.L157F

c.471G>C

14 papers

NM_003000.3

p.L157delFs

c.470delA

1 paper

NM_003000.3

p.Y156_L157delFs

c.467_470del4