Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_003000.3

p.L157delFs

c.470delA

Surrounding Variants

2 papers

NM_003000.3

p.L157fs

c.469_470fs

1 paper

NM_003000.3

p.L157F

c.471G>C

1 paper

NM_003000.3

p.Y156_L157delFs

c.467_470del4

7 papers

NM_003000.3

p.L157W

c.470T>G

2 papers

NM_003000.3

p.L157S

c.470T>C

12 papers

NM_003000.3

p.L157*

c.470T>A

1 paper

NM_003000.3

p.K158*

c.472A>T

1 paper

NM_003000.3

p.L157del1

c.469_471delCAA

1 paper

NM_003000.3

p.L157L

c.469T>C

1 paper

NM_003000.3

p.Y156*

c.468T>G

1 paper

NM_003000.3

p.Y156*

c.468T>A

1 paper

NM_003000.3

p.K158delFs

c.473delT