Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_003000.3

p.P155L

c.464C>T

Surrounding Variants

2 papers

NM_003000.3

p.P155R

c.464C>G

1 paper

NM_003000.3

p.P155P

c.465T>C

1 paper

NM_003000.3

p.P155delFs

c.463delG

1 paper

NM_003000.3

p.S152_P155del0

c.455_463del9

2 papers

NM_003000.3

p.P155S

c.463C>T

1 paper

NM_003000.3

p.P155T

c.463C>A

1 paper

NM_003000.3

p.Y156D

c.466T>G

1 paper

NM_003000.3

p.Y156H

c.466T>C

1 paper

NM_003000.3

p.E154_P155del2

c.460_464del6

6 papers

NM_003000.3

p.Y156F

c.467A>T

2 papers

NM_003000.3

p.Y156C

c.467A>G

1 paper

NM_003000.3

p.E154G

c.461A>G