Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.I153N

c.458T>A

Surrounding Variants

1 paper

NM_003000.3

p.I153T

c.458T>C

1 paper

NM_003000.3

p.I153F

c.457A>T

2 papers

NM_003000.3

p.I153V

c.457A>G

1 paper

NM_003000.3

p.E154*

c.460G>T

1 paper

NM_003000.3

p.E154K

c.460G>A

5 papers

NM_003000.3

p.S152F

c.455C>T

1 paper

NM_003000.3

p.S152Y

c.455C>A

1 paper

NM_003000.3

p.E154G

c.461A>G

1 paper

NM_003000.3

p.E154delFs

c.460delC

1 paper

NM_003000.3

p.S152P

c.454T>C

1 paper

NM_003000.3

p.Y150_K151delFs

c.449_453del5

2 papers

NM_003000.3

p.P155S

c.463C>T