Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003000.3

p.Q149fs

c.445_446fs

Surrounding Variants

9 papers

NM_003000.3

p.Q149*

c.445C>T

4 papers

NM_003000.3

p.Q149insFs

c.445_446ins5

2 papers

NM_003000.3

p.Q149R

c.446A>G

2 papers

NM_003000.3

p.A148fs

c.442_443fs

1 paper

NM_003000.3

p.Q149Fs

c.445_446delinsGGTATCTFs

2 papers

NM_003000.3

p.A148delFs

c.443delG

2 papers

NM_003000.3

p.Q149H

c.447G>T

2 papers

NM_003000.3

p.Q149fs

c.445_446fs

2 papers

NM_003000.3

p.Q149H

c.447G>C

1 paper

NM_003000.3

p.Q149Q

c.447G>A

1 paper

NM_003000.3

p.Q149Fs

c.445_447delinsGGTATCTFs

2 papers

NM_003000.3

p.A148delFs

c.442delC