Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_003000.3

p.Y147C

c.440A>G

Surrounding Variants

1 paper

NM_003000.3

p.Y147F

c.440A>T

1 paper

NM_003000.3

p.Y147_A148insA

c.439_443ins3

4 papers

NM_003000.3

p.Y147*

c.441T>G

4 papers

NM_003000.3

p.Y147*

c.441T>A

1 paper

NM_003000.3

p.N145_F146del0

c.433_438del6

3 papers

NM_003000.3

p.A148T

c.442G>A

1 paper

NM_003000.3

p.Y147delFs

c.441delA

3 papers

NM_003000.3

p.F146L

c.438C>G

4 papers

NM_003000.3

p.F146L

c.438C>A

3 papers

NM_003000.3

p.F146delFs

c.436delA

2 papers

NM_003000.3

p.A148delFs

c.442delC

2 papers

NM_003000.3

p.F146V

c.436T>G