Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003000.3

p.D142V

c.425A>T

Surrounding Variants

1 paper

NM_003000.3

p.D142fs

c.424_425fs

1 paper

NM_003000.3

p.D142fs

c.424_425fs

1 paper

NM_003000.3

p.L143M

c.427T>A

8 papers

NM_003000.3

p.P141_D142Splc

c.424-1G>A

1 paper

NM_003000.3

p.D142_L143delFs

c.424_427del4

1 paper

NM_003000.3

p.P141_D142Splc

c.424-2A>G

1 paper

NM_003000.3

p.L143F

c.429G>T

1 paper

NM_003000.3

p.L143F

c.429G>C

3 papers

NM_003000.3

p.P141_D142Splc

c.424-3C>G

1 paper

NM_003000.3

p.S144R

c.430A>C

1 paper

NM_003000.3

p.S144N

c.431G>A

1 paper

NM_003000.3

p.P141_D142Splc

c.424-5C>G