Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.P141P

c.423C>T

Surrounding Variants

2 papers

NM_003000.3

p.P141_D142Splc

c.423+1G>T

12 papers

NM_003000.3

p.P141_D142Splc

c.423+1G>C

69 papers

NM_003000.3

p.P141_D142Splc

c.423+1G>A

1 paper

NM_003000.3

p.P141delFs

c.423delG

2 papers

NM_003000.3

p.P141L

c.422C>T

2 papers

NM_003000.3

p.P141R

c.422C>G

1 paper

NM_003000.3

p.V140D

c.419T>A

2 papers

NM_003000.3

p.V140delFs

c.418delC

53 papers

NM_003000.3

p.V140F

c.418G>T

1 paper

NM_003000.3

p.V140I

c.418G>A

1 paper

NM_003000.3

p.P131_L139del9

c.391_416del27

1 paper

NM_003000.3

p.L139fs

c.415_416fs