Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.K137E

c.409A>G

Surrounding Variants

1 paper

NM_003000.3

p.I136T

c.407T>C

5 papers

NM_003000.3

p.I136delFs

c.406delT

1 paper

NM_003000.3

p.I136delFs

c.408delT

4 papers

NM_003000.3

p.D138Y

c.412G>T

8 papers

NM_003000.3

p.D138N

c.412G>A

1 paper

NM_003000.3

p.I136_K137del2

c.406_410del6

1 paper

NM_003000.3

p.I136L

c.406A>T

1 paper

NM_003000.3

p.I136V

c.406A>G

3 papers

NM_003000.3

p.V135delFs

c.405delC

1 paper

NM_003000.3

p.V135delFs

c.404delA

1 paper

NM_003000.3

p.D138G

c.413A>G

1 paper

NM_003000.3

p.D138insFs

c.412dupG