Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.Y134Y

c.402T>C

Surrounding Variants

2 papers

NM_003000.3

p.Y134fs

c.400_401fs

1 paper

NM_003000.3

p.Y134delFs

c.401delT

1 paper

NM_003000.3

p.V135_I136ins13

c.403_407ins39

1 paper

NM_003000.3

p.V135L

c.403G>C

1 paper

NM_003000.3

p.V135M

c.403G>A

3 papers

NM_003000.3

p.M133insFs

c.399dupG

1 paper

NM_003000.3

p.Y134H

c.400T>C

1 paper

NM_003000.3

p.Y134fs

c.400_401fs

1 paper

NM_003000.3

p.V135delFs

c.404delA

1 paper

NM_003000.3

p.H132insFs

c.395_396dupAC

1 paper

NM_003000.3

p.M133T

c.398T>C

1 paper

NM_003000.3

p.I136L

c.406A>T