Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.M133T

c.398T>C

Surrounding Variants

1 paper

NM_003000.3

p.H132insFs

c.395_396dupAC

1 paper

NM_003000.3

p.M133V

c.397A>G

3 papers

NM_003000.3

p.M133insFs

c.399dupG

1 paper

NM_003000.3

p.Y134H

c.400T>C

1 paper

NM_003000.3

p.Y134fs

c.400_401fs

1 paper

NM_003000.3

p.H132Q

c.396C>G

2 papers

NM_003000.3

p.H132Q

c.396C>A

10 papers

NM_003000.3

p.H132R

c.395A>G

8 papers

NM_003000.3

p.H132P

c.395A>C

1 paper

NM_003000.3

p.H132delFs

c.394delG

2 papers

NM_003000.3

p.Y134fs

c.400_401fs

1 paper

NM_003000.3

p.Y134Y

c.402T>C