Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003000.3

p.P131fs

c.391_392fs

Surrounding Variants

1 paper

NM_003000.3

p.P129insFs

c.386_387dupCT

1 paper

NM_003000.3

p.L130delFs

c.388_389delAG

1 paper

NM_003000.3

p.V124_L130delins

c.371_390delinsGG

15 papers

NM_003000.3

p.P131R

c.392C>G

1 paper

NM_003000.3

p.K126_P131delFs

c.376_391del16

1 paper

NM_003000.3

p.L130insFs

c.388dupC

1 paper

NM_003000.3

p.L130P

c.389T>C

2 papers

NM_003000.3

p.P131fs

c.391_392fs

15 papers

NM_003000.3

p.P131delFs

c.392delG

2 papers

NM_003000.3

p.H132Y

c.394C>T

2 papers

NM_003000.3

p.L130F

c.388C>T

2 papers

NM_003000.3

p.P131delFs

c.393delT