Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_003000.3

p.I127T

c.380T>C

Surrounding Variants

6 papers

NM_003000.3

p.I127insFs

c.379dupA

58 papers

NM_003000.3

p.I127S

c.380T>G

10 papers

NM_003000.3

p.I127N

c.380T>A

2 papers

NM_003000.3

p.K126delFs

c.378delT

3 papers

NM_003000.3

p.I127fs

c.379_380fs

1 paper

NM_003000.3

p.I127_Y128ins1

c.381_382insAAA

1 paper

NM_003000.3

p.I127fs

c.379_380fs

1 paper

NM_003000.3

p.K126_I127del1

c.378_380delATT

7 papers

NM_003000.3

p.I127L

c.379A>C

1 paper

NM_003000.3

p.I127delFs

c.381delG

1 paper

NM_003000.3

p.N120_I127del8

c.358_380del24

2 papers

NM_003000.3

p.Y128C

c.383A>G