Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.T119T

c.357C>G

Surrounding Variants

1 paper

NM_003000.3

p.T119_N120insFs

c.357_358insT

1 paper

NM_003000.3

p.T119insFs

c.355dupA

1 paper

NM_003000.3

p.T119N

c.356C>A

1 paper

NM_003000.3

p.N120D

c.358A>G

1 paper

NM_003000.3

p.N120I

c.359A>T

4 papers

NM_003000.3

p.N120S

c.359A>G

1 paper

NM_003000.3

p.D118fs

c.352_353fs

1 paper

NM_003000.3

p.C113_D118insFs

c.338_353dup16

4 papers

NM_003000.3

p.L121F

c.361C>T

1 paper

NM_003000.3

p.I117_N120del4

c.349_359del12

4 papers

NM_003000.3

p.D118delFs

c.352delC

3 papers

NM_003000.3

p.R116_D118delFs

c.348_352del5