Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.I117fs

c.349_350fs

Surrounding Variants

1 paper

NM_003000.3

p.I117T

c.350T>C

4 papers

NM_003000.3

p.D118Y

c.352G>T

1 paper

NM_003000.3

p.D118H

c.352G>C

4 papers

NM_003000.3

p.D118N

c.352G>A

1 paper

NM_003000.3

p.D118fs

c.352_353fs

3 papers

NM_003000.3

p.I117fs

c.349_350fs

4 papers

NM_003000.3

p.D118delFs

c.352delC

1 paper

NM_003000.3

p.R116delFs

c.348delC

3 papers

NM_003000.3

p.R116_D118delFs

c.348_352del5

1 paper

NM_003000.3

p.C113_D118delFs

c.339_352del14

1 paper

NM_003000.3

p.R116fs

c.346_347fs

1 paper

NM_003000.3

p.D118fs

c.352_353fs