Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.R115L

c.344G>T

Surrounding Variants

4 papers

NM_003000.3

p.R115Q

c.344G>A

1 paper

NM_003000.3

p.T114delFs

c.341_342delGG

37 papers

NM_003000.3

p.R115*

c.343C>T

3 papers

NM_003000.3

p.R115G

c.343C>G

1 paper

NM_003000.3

p.R116M

c.347G>T

1 paper

NM_003000.3

p.R116insFs

c.347_348insC

1 paper

NM_003000.3

p.R116T

c.347G>C

2 papers

NM_003000.3

p.R116K

c.347G>A

1 paper

NM_003000.3

p.T114_R116delFs

c.342_346del5

1 paper

NM_003000.3

p.C113_T114delFs

c.337_340del4

1 paper

NM_003000.3

p.R116fs

c.346_347fs

2 papers

NM_003000.3

p.T114A

c.340A>G