Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.C113*

c.339C>A

Surrounding Variants

5 papers

NM_003000.3

p.C113insFs

c.337_338insT

2 papers

NM_003000.3

p.C113S

c.338G>C

14 papers

NM_003000.3

p.C113Y

c.338G>A

2 papers

NM_003000.3

p.T114A

c.340A>G

1 paper

NM_003000.3

p.A112_C113delFs

c.334_337del4

1 paper

NM_003000.3

p.C113G

c.337T>G

2 papers

NM_003000.3

p.C113S

c.337T>A

1 paper

NM_003000.3

p.C113_T114delFs

c.337_340del4

2 papers

NM_003000.3

p.A112fs

c.334_335fs

4 papers

NM_003000.3

p.N109_A112delFs

c.325_335del11

37 papers

NM_003000.3

p.R115*

c.343C>T

2 papers

NM_003000.3

p.A112V

c.335C>T