Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_003000.3

p.L111delFs

c.331_332delAG

Surrounding Variants

4 papers

NM_003000.3

p.L111fs

c.331_332fs

2 papers

NM_003000.3

p.L111R

c.332T>G

1 paper

NM_003000.3

p.L111P

c.332T>C

1 paper

NM_003000.3

p.A112S

c.334G>T

2 papers

NM_003000.3

p.T110_L111insFs

c.330_333dup4

1 paper

NM_003000.3

p.A112P

c.334G>C

1 paper

NM_003000.3

p.A112T

c.334G>A

2 papers

NM_003000.3

p.A112V

c.335C>T

1 paper

NM_003000.3

p.L111L

c.331C>T

5 papers

NM_003000.3

p.L111V

c.331C>G

1 paper

NM_003000.3

p.A112G

c.335C>G

1 paper

NM_003000.3

p.L111fs

c.331_332fs