Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_003000.3

p.N109S

c.326A>G

Surrounding Variants

1 paper

NM_003000.3

p.N109fs

c.325_326fs

2 papers

NM_003000.3

p.N109Y

c.325A>T

7 papers

NM_003000.3

p.N109H

c.325A>C

1 paper

NM_003000.3

p.T110S

c.328A>T

1 paper

NM_003000.3

p.T110A

c.328A>G

7 papers

NM_003000.3

p.T110P

c.328A>C

1 paper

NM_003000.3

p.T110insFs

c.328_329insG

2 papers

NM_003000.3

p.G108D

c.323G>A

1 paper

NM_003000.3

p.T110I

c.329C>T

1 paper

NM_003000.3

p.T110S

c.329C>G

1 paper

NM_003000.3

p.T110_L111insFs

c.330_331ins7

1 paper

NM_003000.3

p.T110_L111ins9

c.330_331ins27