Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.G107G

c.321A>G

Surrounding Variants

4 papers

NM_003000.3

p.G107E

c.320G>A

1 paper

NM_003000.3

p.N104_G108delins

c.312_322delinsAT

1 paper

NM_003000.3

p.G107R

c.319G>C

2 papers

NM_003000.3

p.G108D

c.323G>A

1 paper

NM_003000.3

p.G107R

c.319G>A

1 paper

NM_003000.3

p.N106delFs

c.317delT

1 paper

NM_003000.3

p.N109fs

c.325_326fs

2 papers

NM_003000.3

p.N109Y

c.325A>T

6 papers

NM_003000.3

p.N106S

c.317A>G

7 papers

NM_003000.3

p.N109H

c.325A>C

2 papers

NM_003000.3

p.I105_N106del1

c.314_316delTGA

4 papers

NM_003000.3

p.N109S

c.326A>G