Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.I105T

c.314T>C

Surrounding Variants

2 papers

NM_003000.3

p.N104_I105insFs

c.312_313ins7

1 paper

NM_003000.3

p.I105N

c.314T>A

1 paper

NM_003000.3

p.I105fs

c.313_314fs

1 paper

NM_003000.3

p.I105fs

c.313_314fs

1 paper

NM_003000.3

p.I105F

c.313A>T

1 paper

NM_003000.3

p.I105V

c.313A>G

1 paper

NM_003000.3

p.I105L

c.313A>C

1 paper

NM_003000.3

p.M103_N104delFs

c.309_312del4

2 papers

NM_003000.3

p.N104fs

c.310_311fs

1 paper

NM_003000.3

p.N106D

c.316A>G

6 papers

NM_003000.3

p.N106S

c.317A>G

2 papers

NM_003000.3

p.N104S

c.311A>G