Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_003000.3

p.N104Fs

c.311delinsGGFs

Surrounding Variants

2 papers

NM_003000.3

p.N104S

c.311A>G

1 paper

NM_003000.3

p.N104T

c.311A>C

2 papers

NM_003000.3

p.N104insFs

c.311_312insG

2 papers

NM_003000.3

p.N104fs

c.310_311fs

2 papers

NM_003000.3

p.N104fs

c.310_311fs

1 paper

NM_003000.3

p.M103I

c.309G>T

1 paper

NM_003000.3

p.M103insFs

c.308_309ins4

1 paper

NM_003000.3

p.M103fs

c.307_308fs

1 paper

NM_003000.3

p.M103I

c.309G>C

1 paper

NM_003000.3

p.M103I

c.309G>A

1 paper

NM_003000.3

p.I105fs

c.313_314fs

1 paper

NM_003000.3

p.I105F

c.313A>T