Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_003000.3

p.A102T

c.304G>A

Surrounding Variants

1 paper

NM_003000.3

p.A102insFs

c.304_305ins5

1 paper

NM_003000.3

p.C101W

c.303T>G

1 paper

NM_003000.3

p.C101*

c.303T>A

2 papers

NM_003000.3

p.A102V

c.305C>T

1 paper

NM_003000.3

p.A102insFs

c.305_306ins5

1 paper

NM_003000.3

p.S100_A102delFs

c.300_304del5

1 paper

NM_003000.3

p.C98_S100del3

c.292_299del9

3 papers

NM_003000.3

p.C101S

c.302G>C

23 papers

NM_003000.3

p.C101Y

c.302G>A

4 papers

NM_003000.3

p.C101delFs

c.301delA

2 papers

NM_003000.3

p.S100_C101delFs

c.298_301del4

1 paper

NM_003000.3

p.A102fs

c.304_305fs