Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.I97_C98delFs

c.291_292delAG

Surrounding Variants

1 paper

NM_003000.3

p.C98S

c.293G>C

15 papers

NM_003000.3

p.C98Y

c.293G>A

18 papers

NM_003000.3

p.C98R

c.292T>C

1 paper

NM_003000.3

p.C98C

c.294T>C

2 papers

NM_003000.3

p.C98S

c.292T>A

2 papers

NM_003000.3

p.G96_I97del1

c.288_290delATG

1 paper

NM_003000.3

p.G99C

c.295G>T

1 paper

NM_003000.3

p.I97T

c.290T>C

1 paper

NM_003000.3

p.G96_I97del1

c.287_289delTGC

12 papers

NM_003000.3

p.G99D

c.296G>A

1 paper

NM_003000.3

p.I97fs

c.289_290fs

1 paper

NM_003000.3

p.G99delFs

c.296delC