Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.G96Splc

c.287-4T>C

Surrounding Variants

8 papers

NM_003000.3

p.G96Splc

c.287-3C>G

8 papers

NM_003000.3

p.G96Splc

c.287-2A>G

1 paper

NM_003000.3

p.G96Splc

c.287-2A>C

21 papers

NM_003000.3

p.G96Splc

c.287-1G>C

23 papers

NM_003000.3

p.G96S

c.286G>A

16 papers

NM_003000.3

p.G96D

c.287G>A

1 paper

NM_003000.3

p.G96fs

c.286_287fs

1 paper

NM_003000.3

p.G96insFs

c.287dupG

1 paper

NM_003000.3

p.G96Splc

c.287-9C>A

1 paper

NM_003000.3

p.I97fs

c.289_290fs

5 papers

NM_003000.3

p.I97F

c.289A>T

1 paper

NM_003000.3

p.I97T

c.290T>C