Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003000.3

p.R94_E95insFs

c.282_283ins4

Surrounding Variants

1 paper

NM_003000.3

p.C93_R94del1

c.278_280delTGC

1 paper

NM_003000.3

p.R94T

c.281G>C

6 papers

NM_003000.3

p.R94K

c.281G>A

2 papers

NM_003000.3

p.R91_R94del0

c.271_282del12

1 paper

NM_003000.3

p.E95fs

c.283_284fs

1 paper

NM_003000.3

p.S92_C93del0

c.274_279del6

1 paper

NM_003000.3

p.S92_C93del1

c.276_278delCAT

1 paper

NM_003000.3

p.R94delFs

c.281_282delTC

3 papers

NM_003000.3

p.C93F

c.278G>T

1 paper

NM_003000.3

p.G96C

c.286G>T

17 papers

NM_003000.3

p.G96S

c.286G>A

1 paper

NM_003000.3

p.C93Y

c.278G>A