Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_003000.3

p.S92T

c.274T>A

Surrounding Variants

8 papers

NM_003000.3

p.S92P

c.274T>C

3 papers

NM_003000.3

p.R91del1

c.271_272delTCT

1 paper

NM_003000.3

p.R90_R91delFs

c.269_273del5

1 paper

NM_003000.3

p.T88_R91delFs

c.264_273del10

2 papers

NM_003000.3

p.S92*

c.275C>G

3 papers

NM_003000.3

p.S92*

c.275C>A

3 papers

NM_003000.3

p.R91S

c.273A>T

1 paper

NM_003000.3

p.R91R

c.273A>G

2 papers

NM_003000.3

p.R91S

c.273A>C

1 paper

NM_003000.3

p.R91T

c.272G>C

1 paper

NM_003000.3

p.R91K

c.272G>A

1 paper

NM_003000.3

p.C93G

c.277T>G