Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_003000.3

p.R90G

c.268C>G

Surrounding Variants

94 papers

NM_003000.3

p.R90*

c.268C>T

16 papers

NM_003000.3

p.R90Q

c.269G>A

1 paper

NM_003000.3

p.F89L

c.267C>G

1 paper

NM_003000.3

p.F89L

c.267C>A

1 paper

NM_003000.3

p.F89S

c.266T>C

2 papers

NM_003000.3

p.T88_F89del1

c.263_265delAGG

1 paper

NM_003000.3

p.F89L

c.265T>C

7 papers

NM_003000.3

p.R91*

c.271A>T

1 paper

NM_003000.3

p.R91T

c.272G>C

1 paper

NM_003000.3

p.R91K

c.272G>A

5 papers

NM_003000.3

p.T88I

c.263C>T

1 paper

NM_003000.3

p.T88S

c.263C>G