Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.T88S

c.262A>T

Surrounding Variants

1 paper

NM_003000.3

p.T88A

c.262A>G

1 paper

NM_003000.3

p.T88P

c.262A>C

1 paper

NM_003000.3

p.T88_F89ins4

c.262_266ins12

1 paper

NM_003000.3

p.T86insFs

c.258dupT

1 paper

NM_003000.3

p.L87F

c.261G>C

2 papers

NM_003000.3

p.L87delFs

c.260delA

5 papers

NM_003000.3

p.T88I

c.263C>T

1 paper

NM_003000.3

p.T88S

c.263C>G

1 paper

NM_003000.3

p.N81_T88delFs

c.241_262del22

13 papers

NM_003000.3

p.L87S

c.260T>C

1 paper

NM_003000.3

p.L87*

c.260T>A

1 paper

NM_003000.3

p.L87_T88insCAG

c.259_263ins9