Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.S85P

c.253T>C

Surrounding Variants

2 papers

NM_003000.3

p.S85F

c.254C>T

2 papers

NM_003000.3

p.D84E

c.252C>G

1 paper

NM_003000.3

p.S85C

c.254C>G

3 papers

NM_003000.3

p.D84E

c.252C>A

1 paper

NM_003000.3

p.D84_S85delFs

c.250_254del5

2 papers

NM_003000.3

p.D84A

c.251A>C

1 paper

NM_003000.3

p.T86fs

c.256_257fs

1 paper

NM_003000.3

p.V83insFs

c.248dupT

1 paper

NM_003000.3

p.D84N

c.250G>A

1 paper

NM_003000.3

p.T86A

c.256A>G

1 paper

NM_003000.3

p.T86ins1

c.256_257insTTT

2 papers

NM_003000.3

p.S85ins0

c.253_255dupTCT