Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.V83A

c.248T>C

Surrounding Variants

1 paper

NM_003000.3

p.V83G

c.248T>G

1 paper

NM_003000.3

p.E82_V83delFs

c.246_247delCT

1 paper

NM_003000.3

p.V83F

c.247G>T

1 paper

NM_003000.3

p.V83insFs

c.248dupT

1 paper

NM_003000.3

p.D84N

c.250G>A

1 paper

NM_003000.3

p.K78_N81delFs

c.234_243del10

2 papers

NM_003000.3

p.D84A

c.251A>C

1 paper

NM_003000.3

p.E82A

c.245A>C

2 papers

NM_003000.3

p.D84E

c.252C>G

3 papers

NM_003000.3

p.D84E

c.252C>A

1 paper

NM_003000.3

p.S85P

c.253T>C

2 papers

NM_003000.3

p.N81delFs

c.242delT