Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.K80fs

c.238_239fs

Surrounding Variants

1 paper

NM_003000.3

p.K80*

c.238A>T

4 papers

NM_003000.3

p.K80E

c.238A>G

1 paper

NM_003000.3

p.K80Q

c.238A>C

2 papers

NM_003000.3

p.I79delFs

c.237delA

1 paper

NM_003000.3

p.I79M

c.237T>G

1 paper

NM_003000.3

p.K80fs

c.238_239fs

1 paper

NM_003000.3

p.K80insFs

c.239dupA

1 paper

NM_003000.3

p.I79_K80insFs

c.236_239dup4

2 papers

NM_003000.3

p.I79F

c.235A>T

1 paper

NM_003000.3

p.N81Y

c.241A>T

1 paper

NM_003000.3

p.N81D

c.241A>G

1 paper

NM_003000.3

p.I79V

c.235A>G