Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.K78M

c.233A>T

Surrounding Variants

5 papers

NM_003000.3

p.K78R

c.233A>G

5 papers

NM_003000.3

p.K78N

c.234G>T

5 papers

NM_003000.3

p.K78N

c.234G>C

1 paper

NM_003000.3

p.K78delFs

c.233delT

2 papers

NM_003000.3

p.K78*

c.232A>T

2 papers

NM_003000.3

p.K78E

c.232A>G

1 paper

NM_003000.3

p.I77M

c.231C>G

1 paper

NM_003000.3

p.I77fs

c.229_230fs

1 paper

NM_003000.3

p.I77delFs

c.229_230delAT

2 papers

NM_003000.3

p.I79F

c.235A>T

1 paper

NM_003000.3

p.I79V

c.235A>G

2 papers

NM_003000.3

p.I77insFs

c.229dupA