Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.V72insFs

c.214_215insCT

Surrounding Variants

1 paper

NM_003000.3

p.V72I

c.214G>A

1 paper

NM_003000.3

p.V72insFs

c.215_216insC

4 papers

NM_003000.3

p.M71fs

c.211_212fs

1 paper

NM_003000.3

p.M71T

c.212T>C

1 paper

NM_003000.3

p.V72delFs

c.215delA

1 paper

NM_003000.3

p.C68_V72delFs

c.204_214del11

1 paper

NM_003000.3

p.M71fs

c.211_212fs

1 paper

NM_003000.3

p.M71L

c.211A>T

2 papers

NM_003000.3

p.M71V

c.211A>G

5 papers

NM_003000.3

p.P70_M71insFs

c.210_211insC

1 paper

NM_003000.3

p.L73insFs

c.218_219insA

2 papers

NM_003000.3

p.L73*

c.218T>A