Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_003000.3

p.D64E

c.192C>G

Surrounding Variants

2 papers

NM_003000.3

p.D64fs

c.190_191fs

1 paper

NM_003000.3

p.D64insFs

c.191dupA

1 paper

NM_003000.3

p.D64E

c.192C>A

3 papers

NM_003000.3

p.L65F

c.193C>T

1 paper

NM_003000.3

p.L65_N66ins4

c.193_197ins12

2 papers

NM_003000.3

p.D64delFs

c.191_192delGT

1 paper

NM_003000.3

p.K55_D64del0

c.163_192del30

1 paper

NM_003000.3

p.D64V

c.191A>T

1 paper

NM_003000.3

p.D64A

c.191A>C

4 papers

NM_003000.3

p.D64delFs

c.190delC

2 papers

NM_003000.3

p.L65R

c.194T>G

7 papers

NM_003000.3

p.L65P

c.194T>C