Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.Q59H

c.177G>T

Surrounding Variants

2 papers

NM_003000.3

p.Q59H

c.177G>C

11 papers

NM_003000.3

p.T60A

c.178A>G

1 paper

NM_003000.3

p.Q59R

c.176A>G

1 paper

NM_003000.3

p.Q59P

c.176A>C

11 papers

NM_003000.3

p.Q59*

c.175C>T

2 papers

NM_003000.3

p.T60I

c.179C>T

1 paper

NM_003000.3

p.M58_Q59delins

c.174_175delinsTT

1 paper

NM_003000.3

p.T60T

c.180T>C

1 paper

NM_003000.3

p.M58fs

c.172_173fs

1 paper

NM_003000.3

p.M58delFs

c.173delA

1 paper

NM_003000.3

p.M58insFs

c.172dupA

1 paper

NM_003000.3

p.Y61F

c.182A>T