Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_003000.3

p.P56L

c.167C>T

Surrounding Variants

6 papers

NM_003000.3

p.P56fs

c.166_167fs

1 paper

NM_003000.3

p.P56delFs

c.166delG

11 papers

NM_003000.3

p.P56fs

c.166_167fs

1 paper

NM_003000.3

p.P56S

c.166C>T

8 papers

NM_003000.3

p.H57R

c.170A>G

2 papers

NM_003000.3

p.K55R

c.164A>G

1 paper

NM_003000.3

p.H57P

c.170A>C

1 paper

NM_003000.3

p.K55T

c.164A>C

1 paper

NM_003000.3

p.K55insFs

c.164_165insG

1 paper

NM_003000.3

p.P56_H57delFs

c.168_169delGA

2 papers

NM_003000.3

p.H57fs

c.169_170fs

1 paper

NM_003000.3

p.H57Q

c.171T>A