Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.D54V

c.161A>T

Surrounding Variants

1 paper

NM_003000.3

p.D54N

c.160G>A

1 paper

NM_003000.3

p.D48_D54delFs

c.142_161del20

1 paper

NM_003000.3

p.G53fs

c.157_158fs

1 paper

NM_003000.3

p.G53A

c.158G>C

19 papers

NM_003000.3

p.G53E

c.158G>A

2 papers

NM_003000.3

p.K55R

c.164A>G

1 paper

NM_003000.3

p.K55T

c.164A>C

1 paper

NM_003000.3

p.K55insFs

c.164_165insG

4 papers

NM_003000.3

p.G53R

c.157G>C

5 papers

NM_003000.3

p.G53R

c.157G>A

3 papers

NM_003000.3

p.A52delFs

c.155delG

1 paper

NM_003000.3

p.A52delFs

c.154_155delGC